The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for PFCs (PFOA)

Decreased body weight at 1, 5, 10, and 20 days post-natal

Subjects: CD-1 mice

Chemical: PFCs (PFOA)

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in deionized water and delievered through gavage

Exposure duration: gestational day 8 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 9)

Age of measurement: post-natal days 1, 5, 10, 20

Reference [PubMed Link]
White SS, Calafat AM, Kuklenyik Z, Villanueva L, Zehr RD, Helfant L, Strynar MJ, Lindstrom AB, Thibodeaux JR, Wood C, Fenton SE. 2007. Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Toxicol Sci 96(1):133-144.
Study Results Study Details References

Results for PFCs (PFOA)

Decreased body weight in group exposed both in utero and lactionally on post-natal days 3, 5, and 10. As for pups exposed in utero only or lactationally only body weight was decreased on post-natal days 5 and 10.

Subjects: CD-1 mice

Chemical: PFCs (PFOA)

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in deionized water and delievered through gavage

Exposure duration: gestational day 8 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 9)

Age of measurement: post-natal days 1, 3, 5, 10

Reference [PubMed Link]
White SS, Kato K, Jia LT, Basden BJ, Calafat AM, Hines EP, Stanko JP, Wolf CJ, Abbott BD, Fenton SE. 2009. Effects of perfluorooctanoic acid on mouse mammary gland development and differentiation resulting from cross-foster and restricted gestational exposures. Reprod Toxicol 27(3-4):289-298.
Study Results Study Details References

Results for PFCs (PFOA)

Increased relative liver weight in groups exposed in utero only and in utero and lactionally on post-natal days 1, 3, 5, 10. Whereas those exposed lactationally only had increased liver weights on post-natal days 5 and 10.

Subjects: CD-1 mice

Chemical: PFCs (PFOA)

Low doses tested: 5.0 mg/kg bw/d

Route of administration: dissolved in deionized water and delievered through gavage

Exposure duration: gestational day 8 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 9)

Age of measurement: post-natal days 1, 3, 5, 10

Reference [PubMed Link]
White SS, Kato K, Jia LT, Basden BJ, Calafat AM, Hines EP, Stanko JP, Wolf CJ, Abbott BD, Fenton SE. 2009. Effects of perfluorooctanoic acid on mouse mammary gland development and differentiation resulting from cross-foster and restricted gestational exposures. Reprod Toxicol 27(3-4):289-298.
Study Results Study Details References

Results for PFCs (PFOA)

Increased relative liver weight on post-natal day 4, 7, and 14 in females exposed to 1.0 mg/kg.

Subjects: CD-1 mice

Chemical: PFCs (PFOA)

Low doses tested: 0.01, 0.1, 1.0 mg/kg bw/d

Route of administration: dissolved in deionized water and delievered through gavage

Exposure duration: gestational day 10 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 9)

Age of measurement: post-natal day 1, 4, 7, 14, 21

Reference [PubMed Link]
Macon MB, Villanueva LR, Tatum-Gibbs K, Zehr RD, Strynar MJ, Stanko JP, White SS, Helfant L, Fenton SE. 2011. Prenatal perfluorooctanoic acid exposure in CD-1 mice: low-dose developmental effects and internal dosimetry. Toxicol Sci 122(1):134-145.
Study Results Study Details References

Results for PFCs (PFOA)

Decreased body weight in males at birth through weaning and persisting until 71 post-natal days. Female weights were decreased on post-natal day 29.

Subjects: CD-1 mice

Chemical: PFCs (PFOA)

Low doses tested: 5.0 mg/kg bw/d

Other doses tested: 20.0 mg/kg bw/d

Route of administration: dissolved in deionized water and delievered through gavage

Exposure duration: gestational day 10 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 9)

Age of measurement: from post-natal day 1 through 35 weeks

Reference [PubMed Link]
Wolf CJ, Fenton SE, Schmid JE, Calafat AM, Kuklenyik Z, Bryant XA, Thibodeaux J, Das KP, White SS, Lau CS, Abbott BD. 2007. Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures. Toxicol Sci 95(2):462-473.
Study Results Study Details References

Results for PFCs (PFOA)

Increased relative liver weight in both females and males at weaning

Subjects: CD-1 mice

Chemical: PFCs (PFOA)

Low doses tested: 5.0 mg/kg bw/d

Other doses tested: 20.0 mg/kg bw/d

Route of administration: dissolved in deionized water and delievered through gavage

Exposure duration: gestational day 10 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 3 to day 1 of week 9)

Age of measurement: from post-natal day 1 through 35 weeks

Reference [PubMed Link]
Wolf CJ, Fenton SE, Schmid JE, Calafat AM, Kuklenyik Z, Bryant XA, Thibodeaux J, Das KP, White SS, Lau CS, Abbott BD. 2007. Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures. Toxicol Sci 95(2):462-473.