The weeks shown in color represent the start and end points of chemical exposure for each study.

Study Results Study Details References

Results for PFCs (PFOA)

Increased relative liver weight in both females and males at weaning

Subjects: CD-1 mice

Chemical: PFCs (PFOA)

Low doses tested: 5.0 mg/kg bw/d

Other doses tested: 20.0 mg/kg bw/d

Route of administration: dissolved in deionized water and delievered through gavage

Exposure duration: gestational day 15 – gestational day 17 (comparable to human prenatal development from approximately day 1 of week 7 to day 1 of week 9)

Age of measurement: from post-natal day 1 through 35 weeks

Reference [PubMed Link]
Wolf CJ, Fenton SE, Schmid JE, Calafat AM, Kuklenyik Z, Bryant XA, Thibodeaux J, Das KP, White SS, Lau CS, Abbott BD. 2007. Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures. Toxicol Sci 95(2):462-473.