Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
1-hydroxybenzo[a]pyrene
CAS # 13345-23-8
Alternative Name
1-OH-B[a]P
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Fertuck KC, Matthews JB, Zacharewski TR. 2001. Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo. Toxicol Sci 59(2):231-240.
van Lipzig MM, Vermeulen NP, Gusinu R, Legler J, Frank H, Seidel A, Meerman JH. 2005. Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity. Environ Toxicol Pharmacol 19(1):41-55.
*Category References
Fertuck KC, Matthews JB and Zacharewski TR. 2001. Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo. Toxicol Sci 59(2): 231-240.
van Lipzig MM, Vermeulen NP, Gusinu R, Legler J, Frank H, Seidel A and Meerman JH. 2005. Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity. Environ Toxicol Pharmacol 19(1): 41-55.