Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
2,2',3,5',6-pentachlorobiphenyl
CAS # 38379-99-6
Alternative Name
PCB-95
Category*
Industrial additive
Evidence Supporting This Chemical as an Endocrine Disruptor
Pessah, I. N., L. G. Hansen, T. E. Albertson, C. E. Garner, T. A. Ta, Z. Do, K. H. Kim and P. W. Wong (2006). "Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1)." Chem Res Toxicol 19(1): 92-101.
Yang D, Kim KH, Phimister A, Bachstetter AD, Ward TR, Stackman RW, Mervis RF, Wisniewski AB, Klein SL, Kodavanti PR, Anderson KA, Wayman G, Pessah IN, Lein PJ. 2009. Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. Environ Health Perspect 117(3):426-435.
*Category References
Pessah IN, Hansen LG, Albertson TE, Garner CE, Ta TA, Do Z, Kim KH and Wong PW. 2006. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). Chem Res Toxicol 19(1):92-101.