Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
2,3,7,8-tetrachlorodibenzo-p-dioxin
CAS # 1746-01-6
Alternative Name
2,3,7,8-TCDD
Categories*
Byproduct/Intermediate/Reactant
Medical/Veterinary/Research
Evidence Supporting This Chemical as an Endocrine Disruptor
Hojo R, Zareba G, Kai JW, Baggs RB, Weiss B. 2006. Sex-specific alterations of cerebral cortical cell size in rats exposed prenatally to dioxin. J Appl Toxicol 26(1):25-34.
Jablonska O, Piasecka J, Petroff BK, Nynca A, Siawrys G, Wasowska B, Zmijewska A, Lewczuk B, Ciereszko RE. 2011. In vitro effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on ovarian, pituitary, and pineal function in pigs. Theriogenology 76(5):921-932.
Kurita H, Yoshioka W, Nishimura N, Kubota N, Kadowaki T, Tohyama C. 2009. Aryl hydrocarbon receptor-mediated effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on glucose-stimulated insulin secretion in mice. J Appl Toxicol 29(8):689-694.
Nishimura N, Yonemoto J, Miyabara Y, Fujii-Kuriyama Y, Tohyama C. 2005. Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice. Arch Toxicol 79(5):260-267.
Shi ZQ, Valdez KE, Ting AY, Franczak A, Gum SL, Petroff BK. 2007. Ovarian endocrine disruption underlies premature reproductive senescence following environmentally relevant chronic exposure to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biol Reprod 76(2):198-202.
*Category References
US National Library of Medicine. Hazardous Substances Data Bank.