Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
3-methyl-4-nitrophenol
CAS # 2581-34-2
Alternative Name
PNMC
Categories*
Byproduct/Intermediate/Reactant
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Furuta C, Noda S, Li C, Suzuki AK, Taneda S, Watanabe G, Taya K. 2008. Nitrophenols isolated from diesel exhaust particles regulate steroidogenic gene expression and steroid synthesis in the human H295R adrenocortical cell line. Toxicol Appl Pharmacol 229(1):109-120.
Li C, Taneda S, Suzuki AK, Furuta C, Watanabe G, Taya K. 2007. Effects of 3-methyl-4-nitrophenol on the suppression of adrenocortical function in immature male rats. Biol Pharm Bull 30(12):2376-2380.
Taneda S, Mori Y, Kamata K, Hayashi H, Furuta C , Li C, Seki K, Sakushima A, Yoshino S, Yamaki K , Watanabe G, Taya K, Suzuki AK. 2004. Estrogenic and anti-androgenic activity of nitrophenols in diesel exhaust particles (DEP). Biol Pharm Bull 27(6):835-837.
*Category References
Furuta C, Noda S, Li C, Suzuki AK, Taneda S, Watanabe G and Taya K. 2008. Nitrophenols isolated from diesel exhaust particles regulate steroidogenic gene expression and steroid synthesis in the human H295R adrenocortical cell line. Toxicology and Applied Pharmacology 229(1): 109-120.
Li C, Taneda S, Suzuki AK, Furuta C, Watanabe G and Taya K. 2007. Effects of 3-methyl-4-nitrophenol on the suppression of adrenocortical function in immature male rats. Biol Pharm Bull 30(12): 2376-2380.