Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4-nitro-3-phenylphenol
CAS #
Alternative Name
PNMPP
Category*
Byproduct/Intermediate/Reactant
Evidence Supporting This Chemical as an Endocrine Disruptor
Furuta C, Noda S, Li C, Suzuki AK, Taneda S, Watanabe G, Taya K. 2008. Nitrophenols isolated from diesel exhaust particles regulate steroidogenic gene expression and steroid synthesis in the human H295R adrenocortical cell line. Toxicol Appl Pharmacol 229(1):109-120.
Taneda S, Mori Y, Kamata K, Hayashi H, Furuta C , Li C, Seki K, Sakushima A, Yoshino S, Yamaki K , Watanabe G, Taya K, Suzuki AK. 2004. Estrogenic and anti-androgenic activity of nitrophenols in diesel exhaust particles (DEP). Biol Pharm Bull 27(6):835-837.
Trisomboon J, Li CM, Suzuki, A, Watanabe G, Taya K. 2015. 4-Nitro-3-phenylphenol has both androgenic and anti-androgenic-like effects in rats. Journal of Reproduction and Development 61(2):134-137.
*Category References
Furuta C, Noda S, Li C, Suzuki AK, Taneda S, Watanabe G and Taya K. 2008. Nitrophenols isolated from diesel exhaust particles regulate steroidogenic gene expression and steroid synthesis in the human H295R adrenocortical cell line. Toxicology and Applied Pharmacology 229(1): 109-120.