Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

8:2 fluorotelomer alcohol

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CAS # 678-39-7

Alternative Names

8:2 FTOH

1H,1H,2H,2H-perfluorodecan-1-ol

Categories*
Food additives and contact material
Industrial additive
Metabolite/Degradate

Evidence Supporting This Chemical as an Endocrine Disruptor

Ishibashi H, Ishida H, Matsuoka M, Tominaga N and Arizono K. 2007. Estrogenic effects of fluorotelomer alcohols for human estrogen receptor isoforms α and β in vitro. Biological and Pharmaceutical Bulletin 30(7):1358-1359.

Ishibashi H, Yamauchi R, Matsuoka M, Kim JW, Hirano M, Yamaguchi A, Tominaga N and Arizono K. 2008. Fluorotelomer alcohols induce hepatic vitellogenin through activation of the estrogen receptor in male medaka (Oryzias latipes). Chemosphere 71(10):1853-1859.

Liu C, Deng J, Yu L, Ramesh M and Zhou B. 2010. Endocrine disruption and reproductive impairment in zebrafish by exposure to 8: 2 fluorotelomer alcohol. Aquatic Toxicology 96(1):70-76.

Liu C, Du Y and Zhou B. 2007. Evaluation of estrogenic activities and mechanism of action of perfluorinated chemicals determined by vitellogenin induction in primary cultured tilapia hepatocytes. Aquatic toxicology 85(4):267-277.

Liu C, Zhang X, Chang H, Jones P, Wiseman S, Naile J, Hecker M, Giesy JP and Zhou B. 2010. Effects of fluorotelomer alcohol 8: 2 FTOH on steroidogenesis in H295R cells: targeting the cAMP signalling cascade. Toxicol Appl Pharmacol 247(3):222-228.

Maras M, Vanparys C, Muylle F, Robbens J, Berger U, Barber JL, Blust R and De Coen W. 2006. Estrogen-like properties of fluorotelomer alcohols as revealed by MCF-7 breast cancer cell proliferation. Environ Health Perspect 114(1):100-5.

Rosenmai AK, Nielsen FK, Pedersen M, Hadrup N, Trier X, Christensen JH, Vinggaard AM. 2013 Jan 1. Fluorochemicals used in food packaging inhibit male sex hormone synthesis. Toxicol Appl Pharmacol 266(1):132-142.

Rosenmai AK, Nielsen FK, Pedersen M, Hadrup N, Trier X, Christensen JH, Vinggaard AM. 2013 Jan 1. Fluorochemicals used in food packaging inhibit male sex hormone synthesis. Toxicol Appl Pharmacol 266(1):132-142.

*Category References

Rosenmai AK, Nielsen FK, Pedersen M, Hadrup N, Trier X, Christensen JH and Vinggaard AM. 2013. Fluorochemicals used in food packaging inhibit male sex hormone synthesis. Toxicol Appl Pharmacol 266(1):132-142.

Rosenmai AK, Taxvig C, Svingen T, Trier X, Vugt‐Lussenburg BMA, Pedersen M, Lesné L, Jégou B and Vinggaard AM. 2016. Fluorinated alkyl substances and technical mixtures used in food paper‐packaging exhibit endocrine‐related activity in vitro. Andrology 4(4):662-672.

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