Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
isoprene
CAS # 78-79-5
Categories*
Biogenic compound
Byproduct/Intermediate/Reactant
Plastic/Rubber
Unconventional Oil and Gas
Evidence Supporting This Chemical as an Endocrine Disruptor
Doerr JK, Hooser SB, Smith BJ, and Sipes IG. (1995). Ovarian toxicity of 4-vinylcyclohexene and related olefins in B6C3F1 mice: role of diepoxides. Chem Res Tox, 8(7), 963-969.
Melnick RL, Sills RC, Roycroft JH, Chou BJ, Ragan HA, Miller RA. 1994. Isoprene, an endogenous hydrocarbon and industrial chemical, induces multiple organ neoplasia in rodents after 26 weeks of inhalation exposure. Cancer Res 54(20):5333-5339.
Placke ME, Griffis L, Bird M, Bus J, Persing RL, Cox LA, Jr. 1996. Chronic inhalation oncogenicity study of isoprene in B6C3F1 mice. Toxicology 113(1-3):253-262.
*Category References
Colborn T, Schultz K, Herrick L, Kwiatkowski C. 2014. An Exploratory Study of Air Quality near Natural Gas Operations. Hum Ecol Risk Assess 20(1):86-105.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.