Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
2,6-cis-diphenylhexamethylcyclotetrasiloxane
CAS # 33204-76-1
Alternative Names
2,6-cis-[(PhMeSiO)2(Me2SiO)2]
quadrosilan
cisobitan
KABI-1774
Categories*
Industrial additive
Medical/Veterinary/Research
Evidence Supporting This Chemical as an Endocrine Disruptor
Aire TA, Ikegwuonu FI, Heath EH. 1979. Effect of 2,6-cis-diphenylhexamethylcyclotetrasiloxane on the reproductive organs of male mice. Arch Androl 2(4):371-374.
Albanus L, Bjorklund NE, Gustafsson B, Jonsson M. 1975. Forty days oral toxicity of 2,6-cis-diphenylhexamethylcyclotetrasiloxane (KABI 1774)in beagle dogs with special reference to effects on the male reproductive system. Acta Pharmacol Toxicol (Copenh) 36(Suppl 3):93-130.
Hayden JF, Barlow SA. 1972. Structure-activity relationships of organosiloxanes and the female reproductive system. Toxicol Appl Pharmacol 21(1):68-79.
Le Vier RR, Boley WF. 1975. The antigonadotropic activity of an organosiloxane in the male rat: 2,6-cis-diphenylhexamethylcyclotetrasiloxane. Acta Pharmacol Toxicol (Copenh) 36(Suppl 3):55-67.
LeVier RR, Jankowiak ME. 1972. The hormonal and antifertility activity of 2,6-cis-diphenyl?hexamethylcyclotetrasiloxane in the female rat. Biol Reprod 7(2):260-266 [republished as Le Vier RR, Jankowiak ME. 1975. The hormonal and antifertility activity of 2,6-cis-diphenylhexa-methylcyclotetrasiloxane in the female rat. Acta Pharmacol Toxicol (Copenh) 36(Suppl 3):81-92].
Nicander L. 1975. Changes produced in the male genital organs of rabbits and dogs by 2,6-cis-diphenylhexamethylcyclotetrasiloxane (KABI 1774). Acta Pharmacol Toxicol (Copenh) 36(Suppl 3):40-54.
*Category References
Dow Corning Corporation. MSDS - 33 Extreme Low Temperature Bearing Grease, Light
Englebienne P, Van Hoonacker A, Herst CV. 2005. The place of the bioisosteric sila-substitution in drug design. Drug Design Reviews - Online 2(6):467-483.