Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
2-ethylhexyl-4-methoxycinnamate
CAS # 5466-77-3
Alternative Names
octinoxate
octylmethoxycinnamate (OMC)
octyl p-methoxycinnamate
Categories*
Personal care product/Cosmetic ingredient
Pesticide ingredient
Unconventional Oil and Gas
Evidence Supporting This Chemical as an Endocrine Disruptor
Carbone S, Szwarcfarb B, Reynoso R, Ponzo OJ, Cardoso N, Ale E, Moguilevsky JA, Scacchi P. 2010. In vitro effect of octyl - methoxycinnamate (OMC) on the release of Gn-RH and amino acid neurotransmitters by hypothalamus of adult rats. Exp Clin Endocrinol Diabetes 118(5):298-303.
Klammer H, Schlecht C, Wuttke W, Jarry H. 2005. Multi-organic risk assessment of estrogenic properties of octyl-methoxycinnamate in vivo - A 5-day sub-acute pharmacodynamic study with ovariectomized rats. Toxicology 215(1-2):90-96.
Klammer H, Schlecht C, Wuttke W, Schmutzler C, Gotthardt I, Kohrle J, Jarry H. 2007. Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats. Toxicology 238(2-3):192-199.
Kunz PY, Fent K. 2006. Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish. Aquat Toxicol 79(4):305-324.
Rachon D, Rimoldi G, Wuttke W. 2006. In vitro effects of benzophenone-2 and octyl-methoxycinnamate on the production of interferon-gamma and interleukin-10 by murine splenocytes. Immunopharmacol Immunotoxicol 28(3):501-510.
Seidlova-Wuttke D, Jarry H, Christoffel J, Rimoldi G, Wuttke W. 2006. Comparison of effects of estradiol (E2) with those of octylmethoxycinnamate (OMC) and 4-methylbenzylidene camphor (4MBC)--2 filters of UV light - on several uterine, vaginal and bone parameters. Toxicol Appl Pharmacol 210(3):246-254.
*Category References
Orem WH, Tatu CA, Lerch HE, Rice CA, Bartos TT, Bates AL, Tewalt S, Corum MD. 2007. Organic compounds in produced waters from coalbed natural gas wells in the Powder River Basin, Wyoming, USA. Appl Geochem 22(10):2240-2256.
US Dept of Health & Human Services. Household Products Database.
US EPA. InertFinder.
US National Library of Medicine. Haz-Map.