Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

2'-hydroxy-2,3,3',4,4'-pentachlorobiphenyl

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CAS # n/a

Alternative Names

2'-OH-PCB-105

2-hydroxy-2',3,3',4,4'-pentachlorobiphenyl

Category*
Metabolite/Degradate

Evidence Supporting This Chemical as an Endocrine Disruptor

Kester MH, Bulduk S, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MW, Bergman A, Safe SH, Kuiper GG, Schuur AG, Brouwer A, Visser TJ. 2000 . Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. Endocrinology 141(5):1897–1900.

Kramer VJ, Giesy JP. 1999. Specific binding of hydroxylated polychlorinated biphenyl metabolites and other substances to bovine calf uterine estrogen receptor: structure-binding relationships. Sci Total Environ 233(1-3):141-161.

*Category References

ATSDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs).

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