Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
2-hydroxybenzo[a]pyrene
CAS # 56892-30-9
Category*
Medical/Veterinary/Research
Evidence Supporting This Chemical as an Endocrine Disruptor
Nishihara T, Nishikawa J, Kanayama T, Dakeyama F, Saito K, Imagawa M, Takatori S, Kitagawa Y, Hori S, Utsumi H. 2000. Estrogenic activities of 517 chemicals by yeast two-hybrid assay. Journal of Health Science 46(4):282-298.
van Lipzig MM, Vermeulen NP, Gusinu R, Legler J, Frank H, Seidel A, Meerman JH. 2005. Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity. Environ Toxicol Pharmacol 19(1):41-55.
*Category References
Slaga TJ, Bracken WM, Dresner S, Levin W, Yagi H, Jerina DM, Conney AH. 1978. Skin tumor-initiating activities of the twelve isomeric phenols of benzo(a)pyrene. Cancer Res 38(3):678-681.