Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
o-phenylphenol
CAS # 90-43-7
Alternative Names
ortho-phenylphenol
2-phenylphenol
2-biphenylol
2-hydroxybiphenyl
2OH-biphenyl
Categories*
Antimicrobial
Food additives and contact material
Household product ingredient
Industrial additive
Personal care product/Cosmetic ingredient
Pesticide ingredient
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Cappelletti V, Saturno G, Miodini P, Korner W, Daidone MG. 2003. Selective modulation of ER-beta by estradiol and xenoestrogens in human breast cancer cell lines. Cellular & Molecular Life Sciences 60(3):567-576.
Déchaud H, Ravard C, Claustrat F, de la Perrière AB, Pugeat M. 1999. Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG). Steroids 64(5):328-334.
Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.
Kugathas S, Audouze K, Ermler S, Orton F, Rosivatz E, Scholze M, Kortenkamp A. 2015 (in press). Effects of common pesticides on prostaglandin D2 (PGD2) inhibition in SC5 mouse Sertoli cells, evidence of binding at the COX2 active site, and implications for endocrine disruption. Environ Health Perspect.
Okubo T, Kano I. 2003. [Studies on estrogenic activities of food additives with human breast cancer MCF-7 cells and mechanism of estrogenicity by BHA and OPP]. Yakugaku Zasshi 123(6):443-452.
Van den Berg KJ, van Raaij JAGM, Bragt PC, Notten WRF. 1991. Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo. Arch Toxicol 65(1):15-19.
*Category References
Compendium of Pesticide Common Names (CPCN).
US National Library of Medicine. Haz-Map.