Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
3-(4-methylbenzylidene)camphor
CAS # 36861-47-9
Alternative Name
4-methyl-benzylidene camphor (4-MBC)
Category*
Personal care product/Cosmetic ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Durrer S, Ehnes C, Fuetsch M, Maerkel K, Schlumpf M, Lichtensteiger W. 2007. Estrogen sensitivity of target genes and expression of nuclear receptor co-regulators in rat prostate after pre- and postnatal exposure to the ultraviolet filter 4-methylbenzylidene camphor. Environ Health Perspect 115 (Suppl 1):42-50.
Durrer S, Maerkel K, Schlumpf M, Lichtensteiger W. 2005. Estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor. Endocrinology 146(5):2130-2139.
Faass O, Schlumpf M, Reolon S, Henseler M, Maerkel K, Durrer S, Lichtensteiger W. 2009. Female sexual behavior, estrous cycle and gene expression in sexually dimorphic brain regions after pre- and postnatal exposure to endocrine active UV filters. Neurotoxicology 30(2):249-260.
Kunz PY, Fent K. 2006. Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish. Aquat Toxicol 79(4):305-324.
Kunz PY, Galicia HF, Fent K. 2006. Comparison of in vitro and in vivo estrogenic activity of UV filters in fish. Toxicol Sci 90(2):349-361
Maerkel K, Durrer S, Henseler M, Schlumpf M, Lichtensteiger W. 2007. Sexually dimorphic gene regulation in brain as a target for endocrine disrupters: Developmental exposure of rats to 4-methylbenzylidene camphor. Toxicol Appl Pharmacol 218(2):152-165.
Seidlova-Wuttke D, Christoffel J, Rimoldi G, Jarry H, Wuttke W. 2006. Comparison of effects of estradiol with those of octylmethoxycinnamate and 4-methylbenzylidene camphor on fat tissue, lipids and pituitary hormones. Toxicol Appl Pharmacol 214(1):1-7.
Tinwell H, Lefevre PA, Moffat GJ, Burns A, Odum J, Spurway TD, Orphanides G, Ashby J. 2002. Confirmation of uterotrophic activity of 3-(4-methylbenzylidine)camphor in the immature rat. Environ Health Perspect 110(5):533-536.
*Category References
Durrer S, Maerkel K, Schlumpf M, Lichtensteiger W. 2005. Estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor. Endocrinology 146(5):2130-2139.
EWG.