Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
3,3',4,4',5-pentachlorobiphenyl
CAS # 57465-28-8
Alternative Name
PCB-126
Category*
Industrial additive
Evidence Supporting This Chemical as an Endocrine Disruptor
Holene E, Nafstad I, Skaare JU, Bernhoft A, Engen P, Sagvolden T. 1995. Behavioral effects of pre- and postnatal exposure to individual polychlorinated biphenyl congeners in rats. Environ Toxicol Chem 14(6):967-976.
Krishnan V, Safe S. 1993. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships. Toxicol Appl Pharmacol 120(1):55-61.
Ramamoorthy K, Gupta MS, Sun G, McDougal A, Safe SH. 1999. 3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells. Carcinogenesis 20(1):115-123.
Schantz SL, Seo B-W, Moshtaghian J, Amin S. 1997. Developmental exposure to polychlorinated biphenyls or dioxin: do changes in thyroid function mediate effects on spatial learning? Am Zool 37(4):399-408.
Van Birgelen APJM, Smit EA, Kampen IM, Groeneveld CN, Fase KM, Van der Kolk J, Poiger H, Van den Berg M, Koeman JH, Brouwer A. 1995. Subchronic effects of 2,3,7,8-TCDD or PCBs on thyroid hormone metabolism - Use in risk assessment. European Journal of Pharmacology - Environmental Toxicology & Pharmacology Section 293(1):77-85.
*Category References
CDPH. 1988. Polychlorinated Biphenyls (PCBs). Fact Sheet.
UNEP. 1999. Guidlines for the Identification of PCBs and Materials Containing PCBs.
US EPA. 2012. Aroclor and other PCB mixtures.