Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
3,3',4,4'-tetrachlorobiphenyl
CAS # 32598-13-3
Alternative Name
PCB-77
Categories*
Byproduct/Intermediate/Reactant
Industrial additive
Evidence Supporting This Chemical as an Endocrine Disruptor
Durham SK, Brouwer A. 1990. 3,4,3',4'-Tetrachlorobiphenyl distribution and induced effects in the rat adrenal gland: Localization in the zona fasciculata. Lab Invest 62(2):232-239.
Schantz SL, Seo B-W, Moshtaghian J, Amin S. 1997. Developmental exposure to polychlorinated biphenyls or dioxin: do changes in thyroid function mediate effects on spatial learning? Am Zool 37(4):399-408.
Van den Berg KJ, van Raaij JAGM, Bragt PC, Notten WRF. 1991. Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo. Arch Toxicol 65(1):15-19.
van den Berg KJ, Zurcher C, Brouwer A. 1988. Effects of 3,4,3',4'-tetrachlorobiphenyl on thyroid function and histology in marmoset monkeys. Toxicol Lett 41(1):77-86.
*Category References
CDPH. 1988. Polychlorinated Biphenyls (PCBs). Fact Sheet.
Litten S, Fowler B, and Luszniak D. 2002. Identification of a novel PCB source through analysis of 209 PCB congeners by US EPA modified method 1668. Chemosphere 46(9-10):1457-1459.
UNEP. 1999. Guidlines for the Identification of PCBs and Materials Containing PCBs.
US EPA. 2012. Aroclor and other PCB mixtures.