Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
3'-hydroxy-2,3,4,5-tetrachlorobiphenyl
CAS # 67651-37-0
Alternative Names
3'-OH-PCB-61
3-hydroxy-2',3',4',5'-tetrachlorobiphenyl
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Kramer VJ, Giesy JP. 1999. Specific binding of hydroxylated polychlorinated biphenyl metabolites and other substances to bovine calf uterine estrogen receptor: structure-binding relationships. Sci Total Environ 233(1-3):141-161.
Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, Serrano FO. 1995. The E-SCREEN assay as a tool to identify estrogens: An update on estrogenic environmental pollutants. Environ Health Perspect 103 (Suppl. 7):113-122.
*Category References
Kramer VJ, Helferich WG, Bergman A, Klasson-Wehler E, Giesy JP. 1997. Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF-7) cell line. Toxicol Appl Pharmacol 144(2):363-376.