Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
3-hydroxy-benzo[a]pyrene
CAS # 13345-21-6
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Nishihara T, Nishikawa J, Kanayama T, Dakeyama F, Saito K, Imagawa M, Takatori S, Kitagawa Y, Hori S, Utsumi H. 2000. Estrogenic activities of 517 chemicals by yeast two-hybrid assay. Journal of Health Science 46(4):282-298.
van Lipzig MM, Vermeulen NP, Gusinu R, Legler J, Frank H, Seidel A, Meerman JH. 2005. Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity. Environ Toxicol Pharmacol 19(1):41-55.
*Category References
Buratti M, Campo L, Fustinoni S, Cirla PE, Martinotti I, Cavallo D, Foa V. 2007. Urinary hydroxylated metabolites of polycyclic aromatic hydrocarbons as biomarkers of exposure in asphalt workers. Biomarkers 12(3):221-239.