Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
1,2,7,8-tetrachlorodibenzofuran
CAS # 58802-20-3
Alternative Name
1,2,7,8-TCDF
Category*
Byproduct/Intermediate/Reactant
Evidence Supporting This Chemical as an Endocrine Disruptor
Harper N, Wang X, Liu H, Safe S. 1994. Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists. Molecular & Cellular Endocrinology 104(1):47-55.
Liu H, Biegel L, Narasimhan TR, Rowlands C, Safe S. 1992. Inhibition of insulin-like growth factor-I responses in MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Mol Cell Endocrinol 87(1-3):19-28.
*Category References
ATSDR. 1994. Toxicological profile for Chlorodibenzofurans.
Bandiera S, Sawyer T, Romkes M, Zmudzka B, Safe L, Mason G, Keys B, Safe S. 1984. Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology 32(2):131-144.
Mason G, Sawyer T, Keys B, Bandiera S, Romkes M, Piskorska-Pliszczynska J, Zmudzka B, Safe S. 1985. Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-activity relationships. Toxicology 37(1-2):1-12.