Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4-dodecylphenol
CAS # 104-43-8
Alternative Name
p-dodecylphenol
Categories*
Byproduct/Intermediate/Reactant
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Akahori Y, Nakai M, Yamasaki K, Takatsuki M, Shimohigashi Y, Ohtaki M. 2008. Relationship between the results of in vitro receptor binding assay to human estrogen receptor alpha and in vivo uterotrophic assay: Comparative study with 65 selected chemicals. Toxicol in Vitro 22(1):225-231.
Tollefsen KE, Eikvar S, Finne EF, Fogelberg O, Gregersen IK. 2008. Estrogenicity of alkylphenols and alkylated non-phenolics in a rainbow trout (Oncorhynchus mykiss) primary hepatocyte culture. Ecotoxicol Environ Saf 71(2):370-383.
Wetzel CH, Hermann B, Behl C, Pestel E, Rammes G, Zieglgansberger W, Holsboer F, Rupprecht R. 1998. Functional antagonism of gonadal steroids at the 5-hydroxytryptamine type 3 receptor. Mol Endocrinol 12(9):1441-1451.
*Category References
ChemIDPlus Lite.
Kovarova J, Blahova J, Divisova L, Svobodova Z. 2013. Alkylphenol ethoxylates and alkylphenols–update information on occurrence, fate and toxicity in aquatic environment. Polish Journal of Veterinary Sciences 16(4):763-72.
PUBCHEM.