Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4'-hydroxy-2,2',4,6,6'-pentachlorobiphenyl
CAS # 149111-99-9
Alternative Names
4'-OH-PCB-104
4-hydroxy-2,2´,4´,6,6´-pentachlorobiphenyl
"2,4,6,2',6'-pentachloro-4-biphenylol" [sic, Fielden et al. 1997]
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. 1997. Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155). Environ Health Perspect 105(11):1238-1248.
*Category References
ATSDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs).
Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. 1997. Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155). Environ Health Perspect 105(11):1238-1248.