Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

4'-hydroxy-2,3,3',4,5 pentachlorobiphenyl

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CAS # 192190-09-3

Alternative Names

4'-OH-PCB-106

4-hydroxy-2',3,3',4',5'-pentachlorobiphenyl

Category*
Metabolite/Degradate

Evidence Supporting This Chemical as an Endocrine Disruptor

Cheek AO, Kow K, Chen J, McLachlan JA. 1999. Potential mechanisms of thyroid disruption in humans: Interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ Health Perspect 107(4):273-278.

Connor K, Ramamoorthy K, Moore M, Mustain M, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P. 1997. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: Structure-activity relationships. Toxicol Appl Pharmacol 145(1):111-123.

Kester MH, Bulduk S, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MW, Bergman A, Safe SH, Kuiper GG, Schuur AG, Brouwer A, Visser TJ. 2000 . Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. Endocrinology 141(5):1897–1900.

*Category References

ATSDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs).

Okada K, Hashimoto S, Funae Y, Imaoka S. 2009. Hydroxylated polychlorinated biphenyls (PCBs) interact with protein disulfide isomerase and inhibit its activity. Chem Res Toxicol 22(5):899-904.

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