Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4'-hydroxy-2,3',4,5',6-pentachlorobiphenyl
CAS # n/a
Alternative Names
4'-OH-PCB-121
4-hydroxy-2´,3,4´,5,6´-pentachlorobiphenyl
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Cheek AO, Kow K, Chen J, McLachlan JA. 1999. Potential mechanisms of thyroid disruption in humans: Interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ Health Perspect 107(4):273-278.
*Category References
ATSDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs).
Kitamura S, Jinno N, Suzuki T, Sugihara K, Ohta S, Kuroki H, Fujimoto N. 2005. Thyroid hormone-like and estrogenic activity of hydroxylated PCBs in cell culture. Toxicology 208(3):377-387.