Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4'-hydroxy-2,3',4,6-tetrachlorobiphenyl
CAS # 189578-00-5
Alternative Names
4'-OH-PCB-69
4-hydroxy-2',3,4',6'-tetrachlorobiphenyl
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Cheek AO, Kow K, Chen J, McLachlan JA. 1999. Potential mechanisms of thyroid disruption in humans: Interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ Health Perspect 107(4):273-278.
Connor K, Ramamoorthy K, Moore M, Mustain M, Chen I, Safe S, Zacharewski T, Gillesby B, Joyeux A, Balaguer P. 1997. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: Structure-activity relationships. Toxicol Appl Pharmacol 145(1):111-123.
Kester MH, Bulduk S, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MW, Bergman A, Safe SH, Kuiper GG, Schuur AG, Brouwer A, Visser TJ. 2000 . Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. Endocrinology 141(5):1897–1900.
*Category References
ATSDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs).