Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4'-hydroxy-3,3',4,5,5'-pentachlorobiphenyl
CAS # 130689-92-8
Alternative Names
4'-OH-PCB-127
4-hydroxy-3,3´,4´,5,5´-pentachlorobiphenyl
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Kester MH, Bulduk S, Tibboel D, Meinl W, Glatt H, Falany CN, Coughtrie MW, Bergman A, Safe SH, Kuiper GG, Schuur AG, Brouwer A, Visser TJ. 2000 . Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: a novel pathway explaining the estrogenic activity of PCBs. Endocrinology 141(5):1897–1900.
Schuur AG, Brouwer A, Bergman A, Coughtrie MWH, Visser TJ. 1998. Inhibition of thyroid hormone sulfation by hydroxylated metabolites of polychlorinated biphenyls. Chem Biol Interact 109(1-3):293-297.
*Category References
ATSDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs).