Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4-hydroxy-3,5-dichlorobiphenyl
CAS # 1137-59-3
Alternative Name
4-OH-PCB-14
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Cheek AO, Kow K, Chen J, McLachlan JA. 1999. Potential mechanisms of thyroid disruption in humans: Interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ Health Perspect 107(4):273-278.
Gierthy JF, Arcaro KF, Floyd M. 1997. Assessment of PCB estrogenicity in a human breast cancer cell line. Chemosphere 34(5-7):1495-1505.
Kramer VJ, Giesy JP. 1999. Specific binding of hydroxylated polychlorinated biphenyl metabolites and other substances to bovine calf uterine estrogen receptor: structure-binding relationships. Sci Total Environ 233(1-3):141-161.
*Category References
ATSDR. 2000. Toxicological Profile for Polychlorinated Biphenyls (PCBs).
Marchesini GR, Meulenberg E, Haasnoot W, Mizuguchi M, Irth H. 2006. Biosensor recognition of thyroid-disrupting chemicals using transport proteins. Anal Chem 78(4):1107-1114.