Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4-methylcatechol
CAS # 452-86-8
Categories*
Medical/Veterinary/Research
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Lindsay RH, Hill JB, Gaitan E, Cooksey RC, Jolley RL. 1992. Antithyroid effects of coal-derived pollutants. J Toxicol Environ Health 37(4):467-481.
*Category References
Fukuhara K, Ishikawa K, Yasuda S, Kishishita Y, Kim HK, Kakeda T, Yamamoto M, Norii T, Ishikawa T. 2012. Intracerebroventricular 4-methylcatechol (4-MC) ameliorates chronic pain associated with depression-like behavior via induction of brain-derived neurotrophic factor (BDNF). Cell Mol Neurobiol 32(6):971-977.
Ju KS, Parales RE. 2011. Evolution of a new bacterial pathway for 4-nitrotoluene degradation. Mol Microbiol 82(2):355-364.
Lu J, Gao X, Gu J, Zhou L, Guo S, Hao W, Zhou Z, Cao JM. 2012. Nerve sprouting contributes to increased severity of ventricular tachyarrhythmias by upregulating iGluRs in rats with healed myocardial necrotic injury. J Mol Neurosci 48(2):448-455.
Payton F, Bose R, Alworth WL, Kumar AP, Ghosh R. 2011. 4-Methylcatechol-induced oxidative stress induces intrinsic apoptotic pathway in metastatic melanoma cells. Biochem Pharmacol 81(10):1211-1218.
US National Library of Medicine. Haz-Map.