Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4-n-octylphenol
CAS # 1806-26-4
Alternative Names
p-octylphenol
4-octylphenol
Categories*
Byproduct/Intermediate/Reactant
Industrial additive
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J. 2005. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor [gamma]/retinoid X receptor pathway. Mol Pharmacol 67(3):766-774.
Nakagomi M, Suzuki E, Usumi K, Saitoh Y, Yoshimura S, Nagao T, Ono H. 2001. Effects of endocrine disrupting chemicals on the microtubule network in Chinese hamster V79 cells in culture and in Sertoli cells in rats. Teratogenesis, Carcinogenesis & Mutagenesis 21(6):453-462.
Schultz TW, Sinks GD, Cronin MTD. 2000. Effect of substituent size and dimensionality on potency of phenolic xenoestrogens evaluated with a recombinant yeast assay. Environ Toxicol Chem 19(11):2637-2642.
Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olea N, Serrano FO. 1995. The E-SCREEN assay as a tool to identify estrogens: An update on estrogenic environmental pollutants. Environ Health Perspect 103 (Suppl. 7):113-122.
*Category References
US National Library of Medicine. Haz-Map.