Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4-phenylphenol
CAS # 92-69-3
Alternative Names
p-phenylphenol
4-biphenylol
4-hydroxybiphenyl
Categories*
Byproduct/Intermediate/Reactant
Pesticide ingredient
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Cappelletti V, Saturno G, Miodini P, Korner W, Daidone MG. 2003. Selective modulation of ER-beta by estradiol and xenoestrogens in human breast cancer cell lines. Cellular & Molecular Life Sciences 60(3):567-576.
Li J, Ma M, Wang Z. 2010. In vitro profiling of endocrine disrupting effects of phenols. Toxicol In Vitro 24(1):201-207.
Olsen CM, Meussen-Elholm ETM, Samuelsen M, Holme JA, Hongslo JK. 2003. Effects of the environmental oestrogens bisphenol A, tetrachlorobisphenol A, tetrabromobisphenol A, 4-hydroxybiphenyl and 4,4 '-dihydroxybiphenyl on oestrogen receptor binding, cell proliferation and regulation of oestrogen sensitive proteins in the human breast cancer cell line MCF-7. Pharmacology & Toxicology 92(4):180-188.
Schultz TW, Sinks GD, Cronin MTD. 2000. Effect of substituent size and dimensionality on potency of phenolic xenoestrogens evaluated with a recombinant yeast assay. Environ Toxicol Chem 19(11):2637-2642.
van den Berg KJ. 1990. Interaction of chlorinated phenols with thyroxine binding sites of human transthyretin, albumin and thyroid binding globulin. Chem Biol Interact 76(1):63-75.
*Category References
US National Library of Medicine. Haz-Map.