Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
4-tert-octylphenol
CAS # 140-66-9
Alternative Name
4-(1,1,3,3-tetramethylbutyl)phenol
Categories*
Byproduct/Intermediate/Reactant
Industrial additive
Metabolite/Degradate
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Abraham EJ, Frawley LS. 1997. Octylphenol (OP), an environmental estrogen, stimulates prolactin (PRL) gene expression. Life Sci 60(17):1457-1465.
Boockfor FR, Blake CA. 1997. Chronic administration of 4-tert-octylphenol to adult male rats causes shrinkage of the testes and male accessory sex organs, disrupts spermatogenesis, and increases the incidence of sperm deformities. Biol Reprod 57(2):267-277.
Jobling S, Sheahan D, Osborne JA, Matthiessen P, Sumpter JP. 1996. Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Environ Toxicol Chem 15(2):194-202.
Nishihara T, Nishikawa J, Kanayama T, Dakeyama F, Saito K, Imagawa M, Takatori S, Kitagawa Y, Hori S, Utsumi H. 2000. Estrogenic activities of 517 chemicals by yeast two-hybrid assay. Journal of Health Science 46(4):282-298.
Tollefsen KE, Eikvar S, Finne EF, Fogelberg O, Gregersen IK. 2008. Estrogenicity of alkylphenols and alkylated non-phenolics in a rainbow trout (Oncorhynchus mykiss) primary hepatocyte culture. Ecotoxicol Environ Saf 72(2):370-83.
Tran DQ, Klotz DM, Ladlie BL, Ide CF, McLachlan JA, Arnold SF. 1996. Inhibition of progesterone receptor activity in yeast by synthetic chemicals. Biochem Biophys Res Commun 229(2):518-523.
*Category References
Rey Vazquez G, Meijide FJ, Da Cuna RH, Lo Nostro FL, Piazza YG, Babay PA, Trudeau VL, Maggese MC, Guerrero GA. 2009. Exposure to waterborne 4-tert-octylphenol induces vitellogenin synthesis and disrupts testis morphology in the South American freshwater fish Cichlasoma dimerus (Teleostei, Perciformes). Comp Biochem Physiol C Toxicol Pharmacol 150(2):298-306.
US National Library of Medicine. Haz-Map.