Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
Aroclor 1254
CAS # 11097-69-1
Categories*
Household product ingredient
Industrial additive
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Gellert RJ. 1978. Uterotrophic activity of polychlorinated biphenyls (PCB) and induction of precocious reproductive aging in neonatally treated female rats. Environ Res 16(1-3):123-130 .
Hornhardt S, Jenke HS, Michel G. 1994. Polychlorinated biphenyls modulate protooncogene expression in Chang liver cells. FEBS Lett 339(1-2):185-188.
Portigal CL, Cowell SP, Fedoruk MN, Butler CM, Rennie PS, Nelson CC. 2002. Polychlorinated biphenyls interfere with androgen-induced transcriptional activation and hormone binding. Toxicol Appl Pharmacol 179(3):185-194.
Yang D, Kim KH, Phimister A, Bachstetter AD, Ward TR, Stackman RW, Mervis RF, Wisniewski AB, Klein SL, Kodavanti PR, Anderson KA, Wayman G, Pessah IN, Lein PJ. 2009. Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. Environ Health Perspect 117(3):426-435.
Zoeller RT, Dowling AL, Vas AA. 2000. Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain. Endocrinology 141(1):181-189.
*Category References
US National Library of Medicine. Hazardous Substances Data Bank.