Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
atrazine
CAS # 1912-24-9
Category*
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Cooper RL, Stoker TE, Tyrey L, Goldman JM, McElroy WK. 2000. Atrazine disrupts the hypothalamic control of pituitary-ovarian function. Toxicol Sci 53(2):297-307.
Danzo BJ. 1997. Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Environ Health Perspect 105(3):294-301.
Fakhouri WD, Nunez JL, Trail F. 2010. Atrazine binds to the growth hormone-releasing hormone receptor and affects growth hormone gene expression. Environ Health Perspect 118(10):1400-1405.
Fan WQ, Yanase T, Morinaga H, Gondo S, Okabe T, Nomura M, Komatsu T, Morohashi K-I, Hayes TB, Takayanagi R, Nawata H. 2007. Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans. Environ Health Perspect 115(5):720-727.
Giusi G, Facciolo RM, Canonaco M, Alleva E, Belloni V, Dessi'-Fulgheri F, Santucci D. 2006. The endocrine disruptor atrazine accounts for a dimorphic somatostatinergic neuronal expression pattern in mice. Toxicol Sci 89(1):257-264.
Hayes TB, Stuart AA, Mendoza M, Collins A, Noriega N, Vonk A, Johnston G, Liu R, Kpodzo D. 2006. Characterization of atrazine-induced gonadal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17[beta]-estradiol): support for the demasculinization/feminization hypothesis . Environ Health Perspect 114 (Suppl. 1):134-141.
Lim S, Ahn SY, Song IC, Chung MH, Jang HC, Park KS, Lee KU, Pak YK, Lee HK. 2009. Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance. PLoS One 4(4):e5186.
Palma P, Palma VL, Matos C, Fernandes RM, Bohn A, Soares AM, Barbosa IR. 2009. Assessment of the pesticides atrazine, endosulfan sulphate and chlorpyrifos for juvenoid-related endocrine activity using Daphnia magna. Chemosphere 76(3):335-340.
Vonier PM, Crain DA, McLachlan JA, Guillette LJ Jr., Arnold SF. 1996. Interaction of environmental chemicals with the estrogen and progesterone receptors from the oviduct of the American alligator. Environ Health Perspect 104(12):1318-1322.
*Category References
Compendium of Pesticide Common Names (CPCN).
US National Library of Medicine. Haz-Map.