Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
bisphenol A diglycidyl ether
CAS # 1675-54-3
Alternative Names
BADGE
2,2'-bis(4-(2,3-epoxypropoxy)phenyl)propane
2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane
Categories*
Household product ingredient
Industrial additive
Pesticide ingredient
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Bishop-Bailey D, Hla T, Warner TD. 2000. Bisphenol A diglycidyl ether (BADGE) is a PPAR gamma agonist in an ECV304 cell line. Br J Pharmacol 131(4):651-654.
Letcher RJ, Sanderson JT, Bokkers A, Giesy JP, Van Den Berg M. 2005. Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cells. Toxicol Appl Pharmacol 209(2):95-104.
Li H, Ruan XZ, Powis SH, Fernando R, Mon WY, Wheeler DC, Moorhead JF, Varghese Z. 2005. EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism. Kidney Int 67(3):867-874.
Satoh K, Ohyama K, Aoki N, Iida M, Nagai F. 2004. Study on anti-androgenic effects of bisphenol A diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE) and their derivatives using cells stably transfected with human androgen receptor, AR-EcoScreen. Food & Chemical Toxicology 42(6):983-993.
Wright HM, Clish CB, Mikami T, Hauser S, Yanagi K, Hiramatsu R, Serhan CN, Spiegelman BM. 2000. A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation. J Biol Chem 275(3):1873-1877.
*Category References
US EPA. InertFinder.
US National Library of Medicine. Haz-Map.