Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
butyl paraben
CAS # 94-26-8
Alternative Names
n-butyl-4-hydroxybenzoate
N-butyl-p-hydroxybenzoate
Categories*
Antimicrobial
Food additives and contact material
Medical/Veterinary/Research
Personal care product/Cosmetic ingredient
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Boberg J, Metzdorff S, Wortziger R, Axelstad M, Brokken L, Vinggaard AM, Dalgaard M, Nellemann C. 2008. Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats. Toxicology 250(2-3):75-81.
Chen JG, Ahn KC, Gee NA, Gee SJ, Hammock BD, Lasley BL. 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Appl Pharmacol 221(3):278-284.
Gomez E, Pillon A, Fenet H, Rosain D, Duchesne MJ, Nicolas JC, Balaguer P, Casellas C. 2005. Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks. J Toxicol Environ Health A 68(4):239-251.
Song BL, Peng DR, Li HY, Zhang GH, Zhang J, Li KL, Zhao YQ. 1991. Evaluation of the effect of butyl p-hydroxybenzoate on the proteolytic activity and membrane function of human spermatozoa. J Reprod Fertil 91(2):435-440.
Taxvig C, Vinggaard AM, Hass U, Axelstad M, Boberg J, Hansen PR, Frederiksen H, Nellemann C. 2008. Do parabens have the ability to interfere with steroidogenesis? Toxicol Sci 106(1):206-213.
*Category References
US Dept of Health & Human Services. Household Products Database.
US EPA. InertFinder.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.