Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
caffeine
CAS # 58-08-2
Alternative Name
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Categories*
Biogenic compound
Food additives and contact material
Medical/Veterinary/Research
Personal care product/Cosmetic ingredient
Pesticide ingredient
Unconventional Oil and Gas
Evidence Supporting This Chemical as an Endocrine Disruptor
Fort DJ, Stover EL, Propst TL, Faulkner BC, Vollmuth TA, Murray FJ. 1998. Evaluation of the developmental toxicity of caffeine and caffeine metabolites using the frog embryo teratogenesis assay--Xenopus (FETAX). Food & Chemical Toxicology 36(7):591-600.
Tanaka H, Nakazawa K, Arima M. 1987. Effects of maternal caffeine ingestion on the perinatal cerebrum. Biol Neonate 51(6):332-339.
Yun JW, Shin ES, Cho SY, Kim SH, Kim CW, Lee TR, Kim BH. 2008. The effects of BADGE and caffeine on the time-course response of adiponectin and lipid oxidative enzymes in high fat diet-fed C57BL/6J mice: correlation with reduced adiposity and steatosis. Exp Anim 57(5):461-469.
*Category References
Orem WH, Tatu CA, Lerch HE, Rice CA, Bartos TT, Bates AL, Tewalt S, Corum MD. 2007. Organic compounds in produced waters from coalbed natural gas wells in the Powder River Basin, Wyoming, USA. Appl Geochem 22(10):2240-2256.
US EPA. InertFinder.
US National Library of Medicine. Haz-Map.