Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
chlorpyrifos
CAS # 2921-88-2
Categories*
Household product ingredient
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.
Palma P, Palma VL, Matos C, Fernandes RM, Bohn A, Soares AM, Barbosa IR. 2009. Assessment of the pesticides atrazine, endosulfan sulphate and chlorpyrifos for juvenoid-related endocrine activity using Daphnia magna. Chemosphere 76(3):335-340.
Qiao D, Seidler FJ, Abreu-Villaca Y, Tate CA, Cousins MM, Slotkin TA. 2004. Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. Developmental Brain Research 148(1):43-52.
Slotkin TA, Brown KK, Seidler FJ. 2005. Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood. Environ Health Perspect 113(10):1291-1294.
Slotkin TA, Tate CA, Cousins MM, Seidler FJ. 2005. Imbalances emerge in cardiac autonomic cell signaling after neonatal exposure to terbutaline or chlorpyrifos, alone or in combination. Developmental Brain Research 160(2):219-230.
Takeuchi S, Iida M, Yabushita H, Matsuda T, Kojima H. 2008. In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A induction by propanil, diuron and linuron. Chemosphere 74(1):155-165.
Venerosi A, Cutuli D, Colonnello V, Cardona D, Ricceri L, Calamandrei G. 2008. Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood. Neurotoxicol Teratol 30(6):468-474.
Viswanath G, Chatterjee S, Dabral S, Nanguneri SR, Divya G, Roy P. 2010. Anti-androgenic endocrine disrupting activities of chlorpyrifos and piperophos. J Steroid Biochem Mol Biol 120(1):22-29.
*Category References
Compendium of Pesticide Common Names (CPCN).
US National Library of Medicine. Haz-Map.