Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
2,2',3,4,4',5'-hexachlorobiphenyl
CAS # 35065-28-2
Alternative Name
PCB-138
Category*
Industrial additive
Evidence Supporting This Chemical as an Endocrine Disruptor
Bonefeld-Jorgensen EC, Andersen HR, Rasmussen TH, Vinggaard AM. 2001. Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity. Toxicology 158(3):141-153.
Pessah, I. N., L. G. Hansen, T. E. Albertson, C. E. Garner, T. A. Ta, Z. Do, K. H. Kim and P. W. Wong (2006). "Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1)." Chem Res Toxicol 19(1): 92-101.
Portigal CL, Cowell SP, Fedoruk MN, Butler CM, Rennie PS, Nelson CC. 2002. Polychlorinated biphenyls interfere with androgen-induced transcriptional activation and hormone binding. Toxicol Appl Pharmacol 179(3):185-194.
*Category References
CDPH. 1988. Polychlorinated Biphenyls (PCBs). Fact Sheet.
UNEP. 1999. Guidlines for the Identification of PCBs and Materials Containing PCBs.
US EPA. 2012. Aroclor and other PCB mixtures.