Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
dicyclohexyl phthalate
CAS # 84-61-7
Alternative Name
DCHP
Categories*
Household product ingredient
Industrial additive
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Fan WQ, Yanase T, Morinaga H, Gondo S, Okabe T, Nomura M, Komatsu T, Morohashi K-I, Hayes TB, Takayanagi R, Nawata H. 2007. Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans. Environ Health Perspect 115(5):720-727.
Ishido M, Masuo Y, Sayato-Suzuki J, Oka S, Niki E, Morita M. 2004. Dicyclohexylphthalate causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity. J Neurochem 91(1):69-76.
Okubo T, Suzuki T, Yokoyama Y, Kano K, Kano I. 2003. Estimation of estrogenic and anti-estrogenic activities of some phthalate diesters and monoesters by MCF-7 cell proliferation assay in vitro. Biol Pharm Bull 26(8):1219-1224.
Sargis RM, Johnson DN, Choudhury RA, Brady MJ. 2010. Environmental endocrine disruptors promote adipogenesis in the 3T3-L1 cell line through glucocorticoid receptor activation. Obesity (Silver Spring) 18(7):1283-1288.
Yamasaki K, Okuda H, Takeuchi T, Minobe Y. 2009. Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p'-DDE in Sprague-Dawley rats. Toxicol Lett 189(1):14-20.
*Category References
US National Library of Medicine. Haz-Map.