Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

di-isobutyl phthalate

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CAS # 84-69-5

Alternative Name

DiBP

Categories*
Byproduct/Intermediate/Reactant
Household product ingredient
Industrial additive
Plastic/Rubber

Evidence Supporting This Chemical as an Endocrine Disruptor

Boberg J, Metzdorff S, Wortziger R, Axelstad M, Brokken L, Vinggaard AM, Dalgaard M, Nellemann C. 2008. Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats. Toxicology 250(2-3):75-81.

Borch J, Axelstad M, Vinggaard AM, Dalgaard M. 2006. Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis. Toxicol Lett 163(3):183-190.

Hannas BR, Lambright CS, Furr J, Howdeshell KL, Wilson VS, Gray LE Jr. 2011. Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate and diisononyl phthalate. Toxicol Sci 123(1):206-216.

*Category References

US National Library of Medicine. Haz-Map.

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