Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
di-isobutyl phthalate
CAS # 84-69-5
Alternative Name
DiBP
Categories*
Byproduct/Intermediate/Reactant
Household product ingredient
Industrial additive
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Boberg J, Metzdorff S, Wortziger R, Axelstad M, Brokken L, Vinggaard AM, Dalgaard M, Nellemann C. 2008. Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats. Toxicology 250(2-3):75-81.
Borch J, Axelstad M, Vinggaard AM, Dalgaard M. 2006. Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis. Toxicol Lett 163(3):183-190.
Hannas BR, Lambright CS, Furr J, Howdeshell KL, Wilson VS, Gray LE Jr. 2011. Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate and diisononyl phthalate. Toxicol Sci 123(1):206-216.
*Category References
US National Library of Medicine. Haz-Map.