Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
epichlorohydrin
CAS # 106-89-8
Alternative Name
1-chloro-2,3-epoxypropane
Categories*
Byproduct/Intermediate/Reactant
Industrial additive
Pesticide ingredient
Plastic/Rubber
Solvent
Evidence Supporting This Chemical as an Endocrine Disruptor
Cooper ERA, Jones AR, Jackson H. 1974. Effects of alpha-chlorohydrin and related compounds on the reproductive organs and fertility of the male rat. J Reprod Fertil 38(2):379-386.
John JA, Quast JF, Murray FJ, Calhoun LG, Staples RE. 1983. Inhalation toxicity of epichlorohydrin: effects on fertility in rats and rabbits. Toxicol Appl Pharmacol 68(3):415-423.
Kluwe WM, Gupta BN, Lamb JC 4th. 1983. The comparative effects of 1,2-dibromo-3-chloropropane (DBCP) and its metabolites, 3-chloro-1,2-propaneoxide (epichlorohydrin), 3-chloro-1,2- propanediol (alphachlorohydrin), and oxalic acid, on the urogenital system of male rats. Toxicol Appl Pharmacol 70(1):67-86.
Slott VL, Suarez JD, Simmons JE, Perreault SD. 1990. Acute inhalation exposure to epichlorohydrin transiently decreases rat sperm velocity. Fundam Appl Toxicol 15(3):597-606.
Toth GP, Zenick H, Smith MK. 1989. Effects of epichlorohydrin on male and female reproduction in Long- Evans rats. Fundam Appl Toxicol 13(1):16-25.
*Category References
US EPA. InertFinder.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.