Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
ethyl paraben
CAS # 120-47-8
Alternative Names
ethyl-p-hydroxybenzoate
ethyl-4-hydroxybenzoate
Categories*
Antimicrobial
Food additives and contact material
Household product ingredient
Medical/Veterinary/Research
Personal care product/Cosmetic ingredient
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Byford JR, Shaw LE, Drew MG, Pope GS, Sauer MJ, Darbre PD. 2002. Oestrogenic activity of parabens in MCF7 human breast cancer cells. Journal of Steroid Biochemistry & Molecular Biology 80(1):49-60.
Gomez E, Pillon A, Fenet H, Rosain D, Duchesne MJ, Nicolas JC, Balaguer P, Casellas C. 2005. Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks. J Toxicol Environ Health A 68(4):239-251.
Lemini C, Hernández A, Jaimez R, Franco Y, Avila ME, Castell A. 2004. Morphometric analysis of mice uteri treated with the preservatives methyl, ethyl, propyl, and butylparaben. Toxicol Ind Health 20(6-10):123-132.
Song BL, Li HY, Peng DR. 1989. In vitro spermicidal activity of parabens against human spermatozoa. Contraception 39(3):331-335.
Taxvig C, Vinggaard AM, Hass U, Axelstad M, Boberg J, Hansen PR, Frederiksen H, Nellemann C. 2008. Do parabens have the ability to interfere with steroidogenesis? Toxicol Sci 106(1):206-213.
*Category References
US Dept of Health & Human Services. Household Products Database.
US EPA. InertFinder.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.