Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
gamma-hexachlorocyclohexane
CAS # 58-89-9
Alternative Names
lindane
gamma-HCH
gamma-benzene hexachloride
gamma-BHC
Categories*
Personal care product/Cosmetic ingredient
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Danzo BJ. 1997. Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Environ Health Perspect 105(3):294-301.
Goldner WS, Sandler DP, Yu F, Shostrom V, Hoppin JA, Kamel F, LeVan TD. Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study. Journal of occupational and environmental medicine/American College of Occupational and Environmental Medicine. 2013 Oct;55(10):1171.
Jin L, Tran DQ, Ide CF, McLachlan JA, Arnold SF. 1997. Several synthetic chemicals inhibit progesterone receptor-mediated transactivation in yeast. Biochemical & Biophysical Research Communications 233(1):139-146.
Kanayama T, Kobayashi N, Mamiya S, Nakanishi T, Nishikawa J. 2005. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor [gamma]/retinoid X receptor pathway. Mol Pharmacol 67(3):766-774.
Okubo T, Yokoyama Y, Kano K, Soya Y, Kano I. 2004. Estimation of estrogenic and antiestrogenic activities of selected pesticides by MCF-7 cell proliferation assay. Arch Environ Contam Toxicol 46(4):445-453.
Petit F, Le Goff P, Cravedi JP, Valotaire Y, Pakdel F. 1997. Two complementary bioassays for screening the estrogenic potency of xenobiotics: recombinant yeast for trout estrogen receptor and trout hepatocyte cultures. J Mol Endocrinol 19(3):321-335.
Van den Berg KJ, van Raaij JAGM, Bragt PC, Notten WRF. 1991. Interactions of halogenated industrial chemicals with transthyretin and effects on thyroid hormone levels in vivo. Arch Toxicol 65(1):15-19.
*Category References
Compendium of Pesticide Common Names (CPCN).
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.