Endocrine Disruption

TEDX List of Potential Endocrine Disruptors

genistein

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CAS # 446-72-0

Category*
Biogenic compound

Evidence Supporting This Chemical as an Endocrine Disruptor

Davis JN, Kucuk O, Sarkar FH. 2002. Expression of prostate-specific antigen is transcriptionally regulated by genistein in prostate cancer cells. Mol Carcinog 34(2):91-101.

Nishihara T, Nishikawa J, Kanayama T, Dakeyama F, Saito K, Imagawa M, Takatori S, Kitagawa Y, Hori S, Utsumi H. 2000. Estrogenic activities of 517 chemicals by yeast two-hybrid assay. Journal of Health Science 46(4):282-298.

Ohlsson A, Ulleras E, Cedergreen N, Oskarsson A. 2010. Mixture effects of dietary flavonoids on steroid hormone synthesis in the human adrenocortical H295R cell line. Food Chem Toxicol 48(11):3194-3200.

Sanderson JT, Boerma J, Lansbergen GW, van den Berg M. 2002. Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol 182(1):44-54.

Scippo ML, Argiris C, Van De Weerdt C, Muller M, Willemsen P, Martial J, Maghuin-Rogister G. 2004. Recombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors. Analytical & Bioanalytical Chemistry 378(3):664-669.

*Category References

US National Library of Medicine. Hazardous Substances Data Bank.

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