Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
glyphosate formulation
CAS # 1071-83-6 +
Alternative Name
Roundup
Category*
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Benachour N, Sipahutar H, Moslemi S, Gasnier C, Travert C, Séralini GE. 2007. Time- and dose-dependent effects of Roundup on human embryonic and placental cells. Arch Environ Contam Toxicol 53(1):126-133.
de Souza JS, Kizys MML, da Conceição RR, Glebocki G, Romano RM, Ortiga-Carvalho TM, Giannocco G, da Silva IDCG, da Silva MRD, Romano MA, and Chiamolera MI, 2017. Perinatal exposure to glyphosate-based herbicide alters the thyrotrophic axis and causes thyroid hormone homeostasis imbalance in male rats. Toxicology, 377, pp.25-37.
Paganelli A, Gnazzo V, Acosta H, Lopez SL, Carrasco AE. 2010. Glyphosate-Based Herbicides Produce Teratogenic Effects on Vertebrates by Impairing Retinoic Acid Signaling. Chem Res Toxicol 23(10):1586-1595.
Richard S, Moslemi S, Sipahutar H, Benachour N, Seralini GE. 2005. Differential effects of glyphosate and Roundup on human placental cells and aromatase. Environ Health Perspect 113(6):716-720.
*Category References
Martinez TT, Brown K. 1991. Oral and pulmonary toxicology of the surfactant used in Roundup herbicide. Proc West Pharmacol Soc 34:43-46
Williams GM, Kroes R, Munro IC. 2000. Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regul Toxicol Pharmacol 31(2 Pt 1):117-165.