Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
heptachlor
CAS # 76-44-8
Category*
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Abalis IM, Eldefrawi ME, Eldefrawi AT. 1985. High-affinity stereospecific binding of cyclodiene insecticides and gamma-hexachlorocyclohexane to gamma-aminobutyric acid receptors of rat brain. Pesticide Biochemistry & Physiology 24(1):95-102.
Amita Rani BE, Krishnakumari MK. 1995. Prenatal toxicity of heptachlor in albino rats. Pharmacology & Toxicology 76(2):112-114.
Goldner WS, Sandler DP, Yu F, Shostrom V, Hoppin JA, Kamel F, LeVan TD. Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study. Journal of occupational and environmental medicine/American College of Occupational and Environmental Medicine. 2013 Oct;55(10):1171.
Haake J, Kelley M, Keys B, Safe S. 1987. The effects of organochlorine pesticides as inducers of testosterone and benzo[a]pyrene hydroxylases. Gen Pharmacol 18(2):165-169.
Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.
Oduma JA, Wango EO, Oduorokelo D, Makawiti DW, Odongo H. 1995. In vivo and in vitro effects of graded doses of the pesticide heptachlor on female sex steroid hormone production in rats. Comparative Biochemistry & Physiology C: Comparative Pharmacology & Toxicology 111(2):191-196.
*Category References
Compendium of Pesticide Common Names (CPCN).
US National Library of Medicine. Haz-Map.