Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
HPTE
CAS # 2971-36-0
Alternative Names
dihydroxymethoxychlor
bis-hydroxymethoxychlor
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane
Category*
Metabolite/Degradate
Evidence Supporting This Chemical as an Endocrine Disruptor
Blair RM, Fang H, Branham WS, Hass BS, Dial SL, Moland CL, Tong W, Shi L, Perkins R, Sheehan DM. 2000. The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands. Toxicol Sci 54(1):138-153.
Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S. 2000. Interaction of methoxychlor and related compounds with estrogen receptor [alpha] and [beta], and androgen receptor: structure-activity studies. Mol Pharmacol 58(4):852-858.
Maness SC, McDonnell DP, Gaido KW. 1998. Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HEPG2 human hepatoma cells. Toxicol Appl Pharmacol 151(1):135-142.
Zhang HC, Hu XL, Yin DQ, Lin ZF. 2011. Development of molecular docking-based binding energy to predict the joint effect of BPA and its analogs. Hum Exp Toxicol 30(4):318-327.
*Category References
Kupfer D, Bulger WH, Theoharides AD. 1990. Metabolism of methoxychlor by hepatic P-450 monooxygenases in rat and human. 1. Characterization of a novel catechol metabolite. Chem Res Toxicol 3(1):8-16.
Maness SC, McDonnell DP, Gaido KW. 1998. Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HEPG2 human hepatoma cells. Toxicol Appl Pharmacol 151(1):135-142.