Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
linuron
CAS # 330-55-2
Category*
Pesticide ingredient
Evidence Supporting This Chemical as an Endocrine Disruptor
Andrews JE, Gray LE. 1990. The effects of lindane and linuron on calcium metabolism, bone morphometry and the kidney in rats. Toxicology 60(1-2):99-107.
Cook JC, Mullin LS, Frame SR, Biegel LB. 1993. Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats. Toxicol Appl Pharmacol 119(2):195-204.
Kojima H, Katsura E, Takeuchi S, Niiyama K, Kobayashi K. 2004. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect 112(5):524-531.
Kugathas S, Audouze K, Ermler S, Orton F, Rosivatz E, Scholze M, Kortenkamp A. 2015 (in press). Effects of common pesticides on prostaglandin D2 (PGD2) inhibition in SC5 mouse Sertoli cells, evidence of binding at the COX2 active site, and implications for endocrine disruption. Environ Health Perspect.
Lambright C, Ostby J, Bobseine K, Wilson V, Hotchkiss AK, Mann PC, Gray LE Jr. 2000. Cellular and molecular mechanisms of action of linuron: an antiandrogenic herbicide that produces reproductive malformations in male rats. Toxicol Sci 56(2):389-399.
Orton F, Lutz I, Kloas W, Routledge EJ. 2009. Endocrine disrupting effects of herbicides and pentachlorophenol: in vitro and in vivo evidence. Environ Sci Technol 43(6):2144-2150.
Takeuchi S, Iida M, Yabushita H, Matsuda T, Kojima H. 2008. In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A induction by propanil, diuron and linuron. Chemosphere 74(1):155-165.
*Category References
Compendium of Pesticide Common Names (CPCN).
US National Library of Medicine. Haz-Map.