Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
melamine
CAS # 108-78-1
Alternative Name
1,3,5-triazine-2,4,6-triamine
Categories*
Flame retardant
Household product ingredient
Industrial additive
Metabolite/Degradate
Plastic/Rubber
Evidence Supporting This Chemical as an Endocrine Disruptor
Sun, J, Cao, Y, Zhang, X, Zhao, Q, Bao, E, Lv, Y. Melamine negatively affects testosterone synthesis in mice. Res Vet Sci 2016; 109: 135-141.
Sun, J, Zhang, X, Cao, Y, Zhao, Q, Bao, E, Lv, Y. Ovarian Toxicity in Female Rats after Oral Administration of Melamine or Melamine and Cyanuric Acid. Plos One 2016; 11 (2).
Wang Y, Liu F, Wei Y, Liu D. 2011. The effect of exogenous melamine on rat hippocampal neurons. Toxicol Ind Health 27(6):571-576.
Yin RH, Wang WC, Wang XZ, Wang X, Yin RL, Bai WL, Wu CD, Li C, Liu J, Liu BS and He JB. 2014. Effect of melamine on immunohistochemical expression of Bax/Bc1-2 protein in testis and ER-α/PR mRNA in ovary with or without cyanuric acid in mice. Israel Journal of Veterinary Medicine 69(2):74-82.
*Category References
Chou SS, Hwang DF, Lee HF. 2003. High performance liquid chromatographic determination of cyromazine and its derivative melamine in poultry meats and eggs. Journal of Food and Drug Analysis 11(4):290-295.
US National Library of Medicine. Haz-Map.
US National Library of Medicine. Hazardous Substances Data Bank.