Endocrine Disruption
TEDX List of Potential Endocrine Disruptors
2,2',4,4'-tetrahydroxybenzil
CAS # 5394-98-9
Alternative Name
1,2-bis(2,4-dihydroxyphenyl)ethane-1,2-dione
Categories*
Biogenic compound
Medical/Veterinary/Research
Evidence Supporting This Chemical as an Endocrine Disruptor
Blair RM, Fang H, Branham WS, Hass BS, Dial SL, Moland CL, Tong W, Shi L, Perkins R, Sheehan DM. 2000. The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands. Toxicol Sci 54(1):138-153.
*Category References
Ayres DC, Tamm C, Raphael RA, et al. 1994. Dictionary of Natural Products, Volume 1 (p680). Chapman & Hall Chemical Database
Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM. 2005. Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem 48(8):2906-2915.